R440, Astronomy-Mathematics Building, NTU
(台灣大學天文數學館 440室)
Development of a Multisite, Closed-loop Neuromodulator for the Theranosis of Neural Degenerative Diseases
Hsin Chen (National Tsing Hua University)
Abstract
The contemporary microelectronics and information technologies have been employed to brain research and the development of neural prostheses. In addition to rehabilitating sensory or motor functions, stimulating specific brain regions is found useful for treating several neural disorders. However, how electrical stimulation modulates neural activities remains not fully understood. As animal models provide the advantage of recording and stimulating different disease-related regions simultaneously, this talk introduces the latest development of a multisite, closed-loop-controlled microsystem for investigating novel treatments on neural degenerative diseases with freely-moving rats. The algorithms for recognising pathological neural activities automatically are also developed and realized in hardware, so as to control the stimulation in a closed loop and in real time. The pilot studies on the efficacy of treating the Parkinson’s disease with closed-loop-controlled stimulation will be presented and discussed. Finally, the feasibility of modelling and probing how neural dynamics and connectivity are modulated by stimulation will be brought out as an important topic for future collaboration.
Brief Biography
Hsin Chen received his PhD in Electronics at the Edinburgh University, UK in 2004. Afterwards, he joins the EE Dept. at the National Tsing Hua University (NTHU), and is now appointed as a Professor. Hsin has led the Neuro-Engineering Lab, devoted to (1) developing neuromorphic algorithms and realising the algorithms as very-large-scale-integration (VLSI) microsystems (2) developing novel neuro-electronic interfaces for neural prostheses and neural engineering, (3) developing heterogeneous bio-electronic systems for advanced research in neuroscience. The latest research findings have been applied to clinical applications such as the eNose for smelling out pneumonia and the batteryless implantable microsystem for studying the mechanisms of the deep-brain stimulation. Hsin received the Outstanding Young Researcher Award from the Taiwan Integrated Circuit Design (TICD) society in 2013. He is invited as a visiting scholar in the Bordeaux Uni. in France in 2008, in the University d'Evry in France in 2011, and in the Inst. of Neuroinformatics, University of Zurich in Switzerland in 2014. Finally, Hsin Chen is a member of the IEEE, the IEEE EMB, the IEEE CaS, and the TICD societies.
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