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NCTS Seminar on Mathematical Biology
14:20 - 16:20, April 28, 2017 (Friday)
Lecture Room B, 4th Floor, The 3rd General Building, NTHU
(清華大學綜合三館四樓 B演講室)
Structural Analysis For Sensitivity Of Chemical Reaction Networks 1 (2)
Atsushi Mochizuki (Institute of Physical and Chemical Research )


In living cells, chemical reactions are connected by sharing their products and substrates, and form complex network systems, e.g. metabolic network. One experimental approach to study such network systems is sensitivity analysis where the amount or activity of the enzymes is perturbed and responses (concentrations of chemicals or fluxes in the system) are measured. However, due to the complexity of the systems, it has been unclear how the network structures influence the responses of the systems. In this study, we introduce a mathematical method, named structural sensitivity analysis, to determine responses of chemical reaction systems to the perturbation of the enzyme amount/activity based only on network structure. From analyses we found that (1) qualitative responses at a steady state are determined from topological information of network only. We also found that (2) response patterns, e.g., distribution of nonzero responses of chemical concentrations in the network, exhibit two characteristic features, localization and hierarchy, depending on the structure of networks and position of perturbed reactions. Finally, we found (3) a general law which directly connects the network topology and the response patterns, and governs the characteristic patterns of responses. These results imply that network topology is an origin of biological adaptation and robustness. This theorem, which we call the law of localization, is not only theoretically important, but also practically useful for examining real biological systems. We apply our method to several hypothetical and real life chemical reaction networks, including the metabolic network of the E. coli metabolic network.


[1] Mochizuki A., and Fiedler B. (2015) Sensitivity of chemical reaction networks: a structural approach. J. Theor. Biol. 367: 189-202.

[2] Okada T. and Mochizuki A. (2016) Law of Localization in Chemical Reaction Networks. Phys. Rev. Lett. 117, 048101.


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